A Starter's Guide

How These GLP's Work

GLP-1, GIP, and Glucagon Explained

Each of these injectables works by mimicking the natural hormones that regulate appetite, insulin release, and metabolism.

Semaglutide

Semaglutide targets GLP-1 receptors, helping to increase insulin when blood sugar is high, reduce glucagon (which raises blood sugar), slow digestion, and enhance feelings of fullness.

Tirzepatide

Tirzepatide activates both GLP-1 and GIP receptors. This dual action enhances insulin sensitivity, boosts fat metabolism, and delivers stronger appetite control than GLP-1 treatments alone.

Retatrutide

Retatrutide represents the newest generation of metabolic medications. It stimulates three hormone receptors simultaneously. Leading to more effective calorie burning, appetite suppression, and broader metabolic improvements.

Benefits and Effectiveness
for Weight Loss and Blood Sugar Control

Each of these medications offers impressive benefits, but their clinical focus and outcomes vary.

Semaglutide

Proven effective for both type 2 diabetes and weight management, often achieving an average 10–15% body weight reduction.

Tirzepatide

Known for even greater results—up to 20%+ weight loss in studies—while providing powerful improvements in blood sugar control.

Retatrutide

Designed primarily for weight reduction and metabolic health, with trials showing over 24% average body weight reduction and significant increases in energy expenditure.

Dosing

Each treatment is a once-weekly subcutaneous injection, offering convenience and long-lasting results.

Semaglutide

Typically starts at 0.25 mg weekly, increasing up to 2.4 mg for weight management.

Tirzepatide

Starts at 2.5 mg weekly, increasing to 15 mg based on response.

Retatrutide

Begins at 2 mg weekly, titrated up to 8 mg or higher depending on tolerance.

Side Effects

Most users experience mild gastrointestinal symptoms. Nausea, vomiting, or diarrhea during the dose adjustment phase.

Semaglutide

Usually well tolerated after initial weeks.

Tirzepatide

May cause stronger appetite changes during early stages.

Retatrutide

May cause more pronounced early GI effects due to its triple action.

Comparison Table

SEMAGLUTIDE VS TIRZEPATIDE VS RETATRUTIDE

FEATURED PRODUCTS

Semaglutide 12mg Auto-Injector Pen

Semaglutide 12mg Auto-Injector Pen

Semaglutide 12mg Auto-Injector Pen

R 3,450.00
BodyPharm Tirzepatide 60mg

BodyPharm Tirzepatide 60mg

BodyPharm Tirzepatide 60mg

R 4,050.00
BodyPharm Retatrutide 64mg

BodyPharm Retatrutide 64mg

BodyPharm Retatrutide 64mg

R 5,150.00